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clobetasol

CAS 25122-41-2
40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Clobetasol is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Clobetasol (base form) is one of the most potent corticosteroids in the UK-US classification (UK Category 4 / US Class I). EU SCCS has evaluated corticosteroids in cosmetic contexts and recommends against their use in leave-on skin products due to atrophogenic potential. Clobetasol is subject to medical prescribing controls and cannot be legitimately used in cosmetic formulations at any concentration. The complete absence of hazard statements in the provided record reflects its regulated pharmaceutical status rather than low toxicity. Risks include skin atrophy, telangiectasia, systemic absorption, and hypothalamic-pituitary-adrenal (HPA) axis suppression with prolonged use.

Skin benefits

  • Potent anti-inflammatory action (pharmaceutical use only)
  • Suppresses immune-mediated skin reactions (prescription use)

Known concerns

  • Prescription-only drug — not permitted in cosmetic products
  • Potent corticosteroid — skin atrophy and thinning risk
  • Systemic absorption and HPA axis suppression risk
  • EU SCCS advises against corticosteroids in cosmetics
  • Restricted/regulated in most jurisdictions globally

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.