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2-HYDROXYETHYLAMINO-5-NITROANISOLE

CAS 66095-81-6
40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

2-hydroxyethylamino-5-nitroanisole is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

2-Hydroxyethylamino-5-nitroanisole is listed in EU Annex III/236 of Cosmetics Regulation 1223/2009, indicating that its use is restricted to hair dye applications only, subject to concentration limits. The compound carries hazard statements H302 (acute toxicity if swallowed), H315 (skin irritation), H319 (eye irritation), and H335 (respiratory irritation). The nitro group confers both the characteristic yellow-orange colour and contributes to its reactive, potentially sensitising properties. The aromatic amine structure is a structural alert for sensitisation.

Known concerns

  • EU Annex III/236 restricted — hair dye use only with concentration limits
  • Acute oral toxicity (H302)
  • Skin irritation (H315)
  • Eye irritation (H319)
  • Respiratory irritation (H335)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.