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BENZENESULFONYLTROMETHAMIDE

40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A sulfonamide derivative with structural alerts for toxicity, carrying a PubChem safety score of 50 and uncertain EU cosmetic regulatory status that limits its safety profile.

This compound is a sulfonamide derivative (a benzenesulfonyl group attached to a tromethamol-type amide). The sulfonamide pharmacophore is biologically active and raises concerns for potential sensitization and systemic effects upon topical application. Its structure lacks clear precedent in the EU CosIng approved ingredient lists, and the PubChem safety score of 50 reflects moderate concern. Sulfonamides require careful safety evaluation before cosmetic use due to their potential for allergic reactions and biological activity.

Known concerns

  • Sulfonamide moiety with documented sensitization potential
  • Biologically active structure raising systemic absorption concerns
  • Absence from EU CosIng approved ingredient lists
  • Uncertain long-term topical safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.