Other
2-CHLORO-5-NITRO-N-HYDROXYETHYL P-PHENYLENEDIAMINE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
An oxidative hair dye intermediate with skin sensitisation potential, restricted under EU Annex III reference II/1318, permitted only under specific conditions in hair dye formulations.
This nitro-substituted p-phenylenediamine derivative carries the EU hazard statement H317 (skin sensitisation), consistent with its aromatic amine hair dye chemistry. It is listed in EU Annex III under reference II/1318, which specifies conditions and restrictions for its use in hair dye products. Like other oxidative hair dye intermediates, it must be used only in the context of an oxidative (two-component) hair dye system and must not be used in products applied to eyebrows, eyelashes, or consumer-applied products intended for direct skin contact.
Skin benefits
- Used as a coupler or primary intermediate in oxidative hair colouring systems
- Contributes to specific colour tones in permanent hair dye formulations
Known concerns
- Skin sensitiser (H317) — risk of allergic contact dermatitis
- EU Annex III restricted — specific conditions of use apply
- Nitro-group substitution may increase sensitisation potency
- Must not be used in eyelash or eyebrow products
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.