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5-Chloro-1,3-dihydro-2H-indol-2-one

CAS 17630-75-0
40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

5-chloro-1,3-dihydro-2h-indol-2-one is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

5-Chloro-1,3-dihydro-2H-indol-2-one (also known as 5-chloroisatin) is a chlorinated heterocycle based on the indole-2-one (isatin) skeleton. The compound carries hazard classifications including H302 (harmful if swallowed), H317 (skin sensitizer), and H361 (suspected reproductive toxicity). Isatin derivatives have been studied for various pharmacological activities, and the chloro-substitution raises concerns about potential metabolic dechlorination and formation of reactive intermediates. The compound is not listed in EU cosmetics regulation Annexes, effectively prohibiting cosmetic use. The 2-one (lactam) functional group can undergo ring-opening reactions, potentially creating sensitizing intermediates upon skin contact.

Known concerns

  • No EU cosmetic approval
  • Skin sensitizer (H317)
  • Acute oral toxicity (H302)
  • Suspected reproductive toxicant (H361)
  • Potential ring-opening reactivity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.