5-Chloro-1,3-dihydro-2H-indol-2-one
Other
Caution
CAS Number: 17630-75-0
About 5-Chloro-1,3-dihydro-2H-indol-2-one
5-chloro-1,3-dihydro-2h-indol-2-one is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
Detailed Analysis
5-Chloro-1,3-dihydro-2H-indol-2-one (also known as 5-chloroisatin) is a chlorinated heterocycle based on the indole-2-one (isatin) skeleton. The compound carries hazard classifications including H302 (harmful if swallowed), H317 (skin sensitizer), and H361 (suspected reproductive toxicity). Isatin derivatives have been studied for various pharmacological activities, and the chloro-substitution raises concerns about potential metabolic dechlorination and formation of reactive intermediates. The compound is not listed in EU cosmetics regulation Annexes, effectively prohibiting cosmetic use. The 2-one (lactam) functional group can undergo ring-opening reactions, potentially creating sensitizing intermediates upon skin contact.
Known Concerns
- ⚠ No EU cosmetic approval
- ⚠ Skin sensitizer (H317)
- ⚠ Acute oral toxicity (H302)
- ⚠ Suspected reproductive toxicant (H361)
- ⚠ Potential ring-opening reactivity
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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