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clobetasone

CAS 54063-32-0
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Clobetasone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Clobetasone is a synthetic fluorinated corticosteroid of the glucocorticoid class. Topical corticosteroids are anti-inflammatory and immunosuppressive but carry risks of skin atrophy, telangiectasia, and systemic absorption with prolonged use. EU Regulation 1223/2009 does not include corticosteroids among approved cosmetic substances; they are regulated as medicinal products. Cosmetic use of clobetasone is not permitted.

Known concerns

  • EU Annex II — corticosteroids generally prohibited in cosmetics
  • Skin atrophy with prolonged use
  • Risk of systemic absorption
  • Eye toxicity if applied near eyes

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.