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Banned Substance

Colchicine, its salts and derivatives

CAS 64-86-8 Updated
2

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A potent plant alkaloid from autumn crocus — used medically for gout but lethal at low doses. EU Annex II banned for cosmetics. Reproductive toxin, mutagen, and acutely poisonous. No legitimate cosmetic use.

Skin benefits

  • Not applicable - prohibited for cosmetic use

Known concerns

  • EU Annex II banned substance
  • Highly toxic plant alkaloid
  • Reproductive and developmental toxicant
  • Acute oral toxicity in milligram doses
  • No safe cosmetic application

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.