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DEQUALINIUM CHLORIDE

CAS 522-51-0
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Dequalinium Chloride is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Dequalinium chloride (1,1′-decane-1,10-diylbis(4-amino-2-methylquinolinium) dichloride) is a broad-spectrum antiseptic belonging to the quaternary ammonium compounds (QACs) class. In the EU it has limited permitted use as a preservative in certain cosmetic categories, subject to concentration restrictions under Annex V or III of the Cosmetics Regulation. QACs can cause contact dermatitis, mucous membrane irritation, and there are concerns about QAC resistance in bacterial strains.

Skin benefits

  • Broad-spectrum antiseptic activity
  • Preservative function in topical formulations

Known concerns

  • Contact sensitizer — documented allergic contact dermatitis cases
  • Mucous membrane and eye irritation at higher concentrations
  • QAC resistance emerging in bacterial populations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.