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DITHIOTHREITOL

CAS 3483-12-3
58

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Dithiothreitol is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Dithiothreitol (DTT) is a powerful reducing agent used in cosmetic and personal care products primarily for hair permanent wave formulations. It acts by cleaving disulfide bonds in keratin. In skin care, it appears in anti-dandruff or keratolytic formulations at low concentrations. DTT is not listed in EU Annex II (prohibited substances), though its reactivity warrants careful formulation control. It has been associated with contact dermatitis in occupational settings at high concentrations. Restricted use concentrations recommended.

Skin benefits

  • Keratolytic agent (in specific formulations)
  • Hair disulfide bond breaking (in hair care)

Known concerns

  • Skin sensitization and irritation at high concentrations
  • Occupational contact dermatitis risk
  • Strong reducing agent requires careful formulation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.