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DOMIPHEN BROMIDE

CAS 538-71-6
58

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Domiphen Bromide is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Domiphen bromide (CAS 538-71-6, PubChem CID 10866) is a quaternary ammonium compound with antimicrobial and antiseptic properties used in cosmetic and pharmaceutical formulations. It is not listed in EU Annexes II or III under Regulation (EC) 1223/2009, but its use is regulated due to concerns about sensitisation and potential for bacterial resistance. The SCCS has noted that it should be used at controlled concentrations. It is primarily used in oral care and leave-on formulations at low percentages.

Skin benefits

  • Antimicrobial preservation
  • Antiseptic properties

Known concerns

  • Sensitisation potential
  • Antimicrobial resistance concern

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.