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EQUOL

CAS 531-95-3
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Equol is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Equol (7-hydroxy-3-(4-hydroxyphenyl)-chroman) is a non-steroidal estrogen compound produced by gut bacterial biotransformation of the isoflavone daidzin from soy. It has significantly stronger estrogenic activity than its precursors and binds to both ER-alpha and ER-beta receptors. Its use in cosmetics is relatively recent and it does not appear in EU CosIng with specific restrictions. However, the endocrine activity of equol warrants caution — its estrogenic potency is considerably higher than other commonly used phytoestrogens such as genistein or daidzein. Safety data for chronic topical application are limited.

Skin benefits

  • Phytoestrogenic activity may support collagen production and skin elasticity
  • Antioxidant properties
  • Investigated for anti-aging and skin-thickening benefits

Known concerns

  • Potent phytoestrogen with significant endocrine activity
  • Limited long-term topical safety data
  • Potential hormone-sensitive condition interactions
  • Not comprehensively assessed under EU cosmetics safety framework

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.