Skip to content

Banned Substance

Eserine or physostigmine and its salts

CAS 57-47-6 Updated
2

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Physostigmine is a potent cholinesterase-inhibiting alkaloid drug, banned from EU cosmetics. Tiny doses cause systemic toxicity; never appropriate in skincare.

Skin benefits

  • Not for cosmetic use

Known concerns

  • EU Annex II banned alkaloid drug
  • Cholinesterase inhibitor; severe systemic toxicity
  • Narrow therapeutic margin

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related banned substances

2
2,3-Epoxypropan-1-ol (Glycidol)
Banned Substance
 2
4,4'-Bi-o-toluidine (ortho-Tolidine)
Banned Substance
 2
4,4'-Oxydianiline (p-aminophenyl ether) and its salts
Banned Substance
 2
Alkanes, C1-2, if they contain > 0.1% w/w Butadiene
Banned Substance
 2
Alkanes, C4-5, if they contain > 0.1% w/w Butadiene
Banned Substance
 2
Ammonium pentadecafluorooctanoate
Banned Substance
 2
Anthracene oil
Banned Substance
 2
Biphenyl-2-ylamine
Banned Substance

Check your shelf

Find Eserine or physostigmine and its salts in your products.

Scan any cosmetic product with LuxSense to see if it contains Eserine or physostigmine and its salts and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.