Skip to content

Other

ETHYL CARBAZIDO HYALURONATE RH-POLYPEPTIDE-3

72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A bioconjugate of hyaluronic acid and a recombinant human polypeptide designed to combine hydrating and anti-ageing properties in cosmetic formulations.

Ethyl Carbazido Hyaluronate rh-Polypeptide-3 is listed on EU CosIng with a restriction entry II/416 under the Cosmetics Regulation, indicating it requires specific safety evaluation before use. The restriction suggests the Commission identified a potential concern with this particular bioconjugate that warrants case-by-case assessment. Peptide-hyaluronic acid conjugates are innovative cosmetic actives; safety depends on the specific peptide sequence, molecular weight of the HA component, and the carbazido linker stability.

Skin benefits

  • Combines hyaluronic acid hydration with peptide anti-ageing activity
  • May enhance skin elasticity
  • Improved substantivity compared to plain hyaluronic acid

Known concerns

  • EU CosIng restriction II/416 applies — must be evaluated for this specific use
  • Linker (carbazido) stability in skin is not fully established
  • rh-Polypeptide-3 component requires purity verification for recombinant DNA-derived impurities

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related others

72
2,4-DIMETHYL-3-CYCLOHEXENE-1-METHYLACETATE
Other
 72
2-T-BUTYLCYCLOHEXYLOXYBUTANOL
Other
 72
4-METHYLBENZALDEHYDE
Other
 72
ACETAMIDOETHOXYBUTYL TRIMONIUM CHLORIDE
Other
 72
ACETAMIDOETHYL PG-TRIMONIUM CHLORIDE
Other
 72
ADIPIC ACID/1,4-BUTANEDIOL/TEREPHTHALATE COPOLYMER
Other
 72
AGASTACHE RUGOSA STEM OIL
Other
 72
AGAVE RIGIDA
Other

Same plant / compound family

70
ETHYL CARBAZIDO HYALURONATE ACETYL HEXAPEPTIDE-8
Peptide active
 68
ETHYL CARBAZIDO HYALURONATE RH-POLYPEPTIDE-7
Skin Conditioning

Check your shelf

Find ETHYL CARBAZIDO HYALURONATE RH-POLYPEPTIDE-3 in your products.

Scan any cosmetic product with LuxSense to see if it contains ETHYL CARBAZIDO HYALURONATE RH-POLYPEPTIDE-3 and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.