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ETHYL CARBAZIDO HYALURONATE RH-POLYPEPTIDE-3

72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A bioconjugate of hyaluronic acid and a recombinant human polypeptide designed to combine hydrating and anti-ageing properties in cosmetic formulations.

Ethyl Carbazido Hyaluronate rh-Polypeptide-3 is listed on EU CosIng with a restriction entry II/416 under the Cosmetics Regulation, indicating it requires specific safety evaluation before use. The restriction suggests the Commission identified a potential concern with this particular bioconjugate that warrants case-by-case assessment. Peptide-hyaluronic acid conjugates are innovative cosmetic actives; safety depends on the specific peptide sequence, molecular weight of the HA component, and the carbazido linker stability.

Skin benefits

  • Combines hyaluronic acid hydration with peptide anti-ageing activity
  • May enhance skin elasticity
  • Improved substantivity compared to plain hyaluronic acid

Known concerns

  • EU CosIng restriction II/416 applies — must be evaluated for this specific use
  • Linker (carbazido) stability in skin is not fully established
  • rh-Polypeptide-3 component requires purity verification for recombinant DNA-derived impurities

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.