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FORMONONETIN

CAS 485-72-3
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Formononetin is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Formononetin is an O-methylated isoflavone found in plants such as red clover and soy. As a phytoestrogen, it binds to estrogen receptors and has documented endocrine-disrupting potential in vitro and in vivo. The EU CosIng database has no specific entry listing formononetin as approved for cosmetic use, and its status is effectively 'not listed' — meaning it cannot be used without explicit authorization. Scientific literature raises concerns about hormonal activity, particularly for use in leave-on products near sensitive areas.

Skin benefits

  • Antioxidant properties documented in vitro
  • May support collagen synthesis inhibition of matrix metalloproteinases (theoretical)

Known concerns

  • Endocrine-disrupting potential — phytoestrogenic activity via ER binding
  • Not listed in CosIng Annexes — unauthorized cosmetic use
  • Potential reproductive/developmental effects at high exposure
  • May interfere with hormonal pathways

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.