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furtrethonium iodide

CAS 541-64-0
40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Furtrethonium iodide is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Furtrethonium (furfuryltrimethylammonium iodide) is a synthetic quaternary ammonium compound structurally related to muscarinic agonists such as methacholine. The furfuryl (furan) substituent confers increased lipophilicity compared to acetylcholine. It has been used in ophthalmic formulations to stimulate tear secretion and ciliary body activity in dry eye conditions, and in pharmacological research as a muscarinic probe. The quaternary ammonium structure prevents CNS penetration but allows peripheral muscarinic effects. Limited toxicological data are available for cosmetic-type dermal exposure, and it is not listed in EU CosIng for cosmetic use.

Skin benefits

  • Muscarinic agonist activity may increase skin hydration via eccrine gland stimulation
  • Historical ophthalmic use suggests local tolerability

Known concerns

  • Muscarinic agonist — may cause parasympathomimetic side effects (salivation, lacrimation)
  • Limited toxicological safety data for cosmetic dermal application
  • Not listed in EU CosIng — authorization status unclear
  • Iodide counterion may cause irritation in iodide-sensitive individuals

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.