Skin Conditioning
HEXAPEPTIDE-85 HYDROXYPROLINE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A synthetic signal peptide tagged with hydroxyproline, sold for anti-aging and firming claims. Low irritation but thin independent efficacy data.
Hexapeptide-85 hydroxyproline is a synthetic six-amino-acid peptide conjugated with hydroxyproline — an amino acid characteristic of collagen. It is marketed as a signal peptide that supports extracellular matrix maintenance. Peptides of this class are typically used at micro-concentrations (ppm to low ppm) and are generally non-irritating. However, topical penetration of intact peptides is limited, and clinical efficacy data is almost exclusively supplier-generated. No SCCS opinion or CIR review for this specific peptide exists. No GHS hazards at cosmetic use levels.
Function
Skin benefits
- Signal peptide marketed for collagen-supporting activity
- Hydroxyproline conjugation mimics native collagen structure
- Low irritation profile at cosmetic use levels
Known concerns
- Marketing claims exceed independent clinical evidence
- Topical penetration of peptides remains limited
- Proprietary material with no SCCS dossier
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.