Skin Conditioning
TETRAPEPTIDE-44
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A synthetic four-amino-acid peptide used as a skin-conditioning signal. Safe at typical use levels; efficacy claims largely supplier-driven.
Tetrapeptide-44 is a 4-residue synthetic peptide supplied primarily as an aqueous concentrate. Tetrapeptides as a class are among the best-tolerated cosmetic actives — their size precludes immune recognition as allergens, and they are readily metabolised to natural amino acids. No GHS hazards are reported. Regulatory status is limited: no CIR or SCCS monograph covers this specific INCI, and independent efficacy studies are rare, with most available data originating from ingredient suppliers. Concentrations in finished products are typically in the low ppm range.
Function
Skin benefits
- Non-sensitizing
- Biodegradable to amino acids
- Claimed smoothing effect
Known concerns
- Limited independent research
- No regulatory review
- Supplier-sourced efficacy
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.