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Skin Conditioning

HYDROLYZED WHEAT GLUTEN

CAS 100684-25-1 Updated
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Wheat-gluten peptides used to condition skin and hair. Linked to facial-wash sensitisation cases in Japan when high molecular-weight peptides (Glupearl 19S) were used.

Hydrolyzed wheat gluten (CAS 100684-25-1) consists of peptides from acid or enzymatic digestion of wheat gluten. The 2018 CIR reassessment (after Japanese wheat-allergy cases from Glupearl 19S soap) concluded the ingredient is safe only when formulated to minimize peptides of molecular weight greater than 3500 Da, avoided on damaged skin and in products that may contact mucous membranes. Functions: skin/hair conditioning, film formation. Used at 0.1–2%. Coeliac patients: topical use is generally not systemic but specialist products should avoid it.

Function

MOISTURISINGSKIN CONDITIONINGSKIN PROTECTING

Skin benefits

  • Film-forming peptides on skin/hair
  • Skin and hair conditioning
  • Humectant-like hygroscopic behavior

Known concerns

  • Historic sensitisation incidents with high-MW gluten peptides (Glupearl 19S)
  • CIR: safe only when peptides are kept below 3500 Da
  • Unsuitable for damaged skin and mucous membranes

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related skin conditionings

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.