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HYDROXYCAPRYLOYL PHYTOSPHINGOSINE

CAS 173840-45-4
82

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Hydroxycapryloyl Phytosphingosine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Hydroxycapryloyl phytosphingosine is a conjugate of 8-carbon hydroxy fatty acid (hydroxycapryloyl) with phytosphingosine, a naturally occurring sphingoid base found in human skin. It functions as a skin-identical ingredient that strengthens the skin barrier, reduces transepidermal water loss (TEWL), and supports the skin's natural lipid matrix. Phytosphingosine and its derivatives have documented anti-inflammatory and antimicrobial properties. The EU CosIng database lists phytosphingosine derivatives as approved cosmetic ingredients with no restrictions. This compound is well-tolerated across all skin types including sensitive skin, with efficacy supported by published clinical data.

Skin benefits

  • Strengthens skin barrier function
  • Reduces transepidermal water loss (TEWL)
  • Anti-inflammatory properties
  • Supports natural ceramide synthesis
  • Antimicrobial properties
  • Suitable for sensitive and compromised skin

Known concerns

  • Extremely well-tolerated with minimal concerns
  • Use in combination with other sphingolipids may enhance ceramide synthesis

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.