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ILOMASTAT

CAS 142880-36-2
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Ilomastat is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Ilomastat (GM6001) is a broad-spectrum hydroxamate-based matrix metalloproteinase (MMP) inhibitor originally developed for pharmaceutical applications including wound healing, corneal disease, and cancer. While MMP inhibitors have theoretical anti-aging skin benefits by preventing collagen degradation, ilomastat lacks adequate safety data for cosmetic topical use. It is not listed in CosIng and would require extensive safety evaluation before cosmetic formulation. Systemic MMP inhibition raises concerns about interference with normal tissue remodeling.

Skin benefits

  • Theoretical anti-aging via MMP inhibition
  • May support collagen preservation

Known concerns

  • Not listed in CosIng — lacks EU cosmetic approval
  • Insufficient topical safety data
  • Broad MMP inhibition may interfere with normal skin remodeling
  • Developed as a pharmaceutical agent — requires prescription-level evaluation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.