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Hair dye intermediate

M-PHENYLENEDIAMINE

CAS 108-45-2
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

m-Phenylenediamine is an aromatic diamine once used as a permanent hair dye coupler. It is now prohibited in EU cosmetics due to strong sensitization and genotoxicity concerns and is not permitted in finished products.

Skin benefits

  • Historically used as oxidative hair dye coupler
  • Produces dark hair color shades when combined with developers
  • Provides color permanence in hair dye formulations

Known concerns

  • Strong skin sensitizer causing allergic contact dermatitis
  • Classified as suspected mutagen and carcinogen in animal studies
  • Banned in cosmetics in the EU under Regulation 1223/2009 Annex II
  • Cross-reacts with PPD in dye-allergic individuals

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.