Skip to content

Other

4-ETHOXY-M-PHENYLENEDIAMINE SULFATE

CAS 6219-69-8 / 68015-98-5
27

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An ethoxy-substituted aromatic diamine hair dye intermediate restricted under EU Regulation II/406, with skin sensitization and mutagenicity concerns.

4-Ethoxy-m-phenylenediamine sulfate is restricted under EU Regulation 1223/2009 Annex II entry 406. The ethoxy substituent on the aromatic ring modifies the electronic properties and reactivity of the diamine, which affects both its dyeing performance and its biological activity. Like other aromatic diamine hair dye intermediates, it carries sensitization potential and requires strict concentration controls. Multiple CAS numbers reflect different salt forms and hydrates. The compound has been associated with positive mutagenicity assay results in some studies, which has contributed to its restriction in cosmetic hair dye formulations in the EU. Professional use is typically limited to oxidation hair dye systems with appropriate PPE.

Skin benefits

  • Hair dye intermediate for specialized shade formulations in professional settings

Known concerns

  • EU Annex II/406 restricted hair dye intermediate
  • Skin sensitization
  • Mutagenicity concerns
  • Professional use only — concentration limits apply

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

27
4-FLUORO-6-METHYL-M-PHENYLENEDIAMINE SULFATE
Other
 27
N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE
Other
 28
1-(4’-Aminophenylazo)-2-methyl- 4-(bis-2-hydroxyethyl) aminobenzene
Other
 28
2,2'-Bioxirane (1,2:3,4-Diepoxybutane)
Other
 28
2-((2-METHYLAMINO)ETHOXY)-P-PHENYLENEDIAMINE
Other
 28
2-(2,2-DIMETHOXY)ETHOXY-P-PHENYLENEDIAMINE
Other
 28
2-(2-(2-METHOXYETHOXY)ETHOXY)-P-PHENYLENEDIAMINE
Other
 28
2-(2-OXOBUTOXY)-P-PHENYLENEDIAMINE
Other

Check your shelf

Find 4-ETHOXY-M-PHENYLENEDIAMINE SULFATE in your products.

Scan any cosmetic product with LuxSense to see if it contains 4-ETHOXY-M-PHENYLENEDIAMINE SULFATE and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.