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MAGNESIUM THIOGLYCOLATE

CAS 63592-16-5
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A magnesium salt of thioglycolic acid used in permanent wave and hair straightening formulations, restricted under EU Annex III/2a due to concerns related to thiourea and nitrosamine formation potential.

Magnesium thioglycolate is the magnesium salt of thioglycolic acid (mercaptoacetic acid), used as a reducing agent in permanent wave, hair straightening, and depilatory products. EU Annex III/2a listing subjects it to specific concentration limits and conditions for use. The thioglycolate anion can form nitrosamines under certain conditions (when in contact with nitrosating agents), which is the primary regulatory concern. Professional use formulations typically contain higher concentrations.

Known concerns

  • EU Annex III/2a restriction applies
  • Nitrosamine formation potential when in contact with nitrosating agents
  • Skin and respiratory irritant (thiol compounds)
  • Should not be used in combination with nitrogen-containing compounds

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.