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MENADIONE

CAS 58-27-5
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Menadione is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Menadione (2-methyl-1,4-naphthoquinone) is a synthetic form of vitamin K that has been used in cosmetic formulations for its purported skin-conditioning properties. However, it is restricted in cosmetic products within the EU under Regulation (EC) No 1223/2009 due to toxicity concerns, including potential genotoxicity and liver toxicity at elevated exposures. It is not permitted in aerosolized cosmetic products (sprays) due to inhalation toxicity risks. The substance is also subject to IFRA restrictions.

Skin benefits

  • Vitamin K derivative (skin conditioning)

Known concerns

  • EU restriction applies (IFRA)
  • Hepatotoxicity concerns
  • Not permitted in aerosol/spray cosmetics
  • Potential genotoxicity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.