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meprednisone

CAS 1247-42-3
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Meprednisone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Meprednisone (11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione) is a synthetic corticosteroid approximately 5× more potent than hydrocortisone. Corticosteroids are restricted under EU Annex III of the Cosmetics Regulation when present for their anti-inflammatory action. Chronic topical corticosteroid use causes skin thinning, striae, and systemic absorption effects. As a pharmaceutical-grade anti-inflammatory, meprednisone has no safe use level in cosmetic leave-on products.

Known concerns

  • EU Annex III restricted — corticosteroid with high anti-inflammatory potency
  • Skin atrophy and telangiectasia risk with chronic use
  • Systemic glucocorticoid effects possible

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.