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METHOXY PEG-36 BILIRUBINAMIDE

48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A PEG-36 ethoxylated derivative of bilirubinamide with limited public safety data; its macromolecular nature and potential residual monomer content warrant caution in cosmetic formulations.

Methoxy PEG-36 bilirubinamide is a polyethylene glycol derivative (average EO chain length 36) of bilirubinamide, designed to confer water solubility to the naturally lipid-soluble bilirubin molecule. PEGylated bilirubin derivatives are primarily research compounds used in drug-delivery contexts; cosmetic use is uncommon and safety data are sparse. PEG derivatives with moderate chain lengths may cause skin penetration enhancement in damaged skin, and residual monomers from polymerisation could present sensitisation risks.

Skin benefits

  • Potential antioxidant properties inherited from bilirubin scaffold
  • May support skin lipid barrier in emollient formulations

Known concerns

  • Limited cosmetic safety data and no established safe concentration
  • Potential PEG-related sensitisation from polymerisation residues
  • Possible skin penetration enhancement with damaged epidermis

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.