Skip to content

Other

Methylprednisolone aceponate

CAS 86401-95-8
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Methylprednisolone Aceponate is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Methylprednisolone aceponate (MPA) is a diester corticosteroid (21-acetate + 17-propionate) providing high lipophilicity and sustained topical activity. Like clobetasol propionate, it is a prescription pharmaceutical with well-documented atrophogenic effects on skin with chronic use. The hazard statements H360 (developmental/reproductive toxicity), H372 (specific target organ toxicity — adrenal axis), and H361 (suspected reproductive toxicity) reflect systemic concern from dermal absorption. EU SCCS has repeatedly concluded that corticosteroids have no place in cosmetic formulations due to their pharmacological mechanism of action. The restricted pharmaceutical status (prescription-only in most EU member states) is the key regulatory fact here.

Skin benefits

  • Potent anti-inflammatory (prescription use)

Known concerns

  • Prescription pharmaceutical — not permitted in cosmetic products
  • Reproductive/developmental toxicity (H360, H361)
  • Skin atrophy with chronic use
  • Systemic effects via HPA axis suppression
  • EU SCCS advises against corticosteroids in cosmetics
  • No cosmetic ingredient status in CosIng

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

35
1,3-Benzenediamine, 4-methyl-, hydrochloride (1:1)
Other
 35
1,5-Di-(beta-hydroxyethylamino)-2-nitro-4-chlorobenzene (see note 17)
Other
 35
2,2'-Methylenebis(6-bromo-4-chlorophenol)
Other
 35
2,4-DIAMINO-5-METHYLPHENETOLE HCL
Other
 35
2-CHLORO-6-ETHYLAMINO-4-NITROPHENOL
Other
 35
2-Ethylhexyl 4-(dimethylamino)benzoate / Padimate O (USAN:BAN)
Other
 35
3-(p-Chlorophenoxy)-propane-1,2-diol
Other
 35
3-Hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide
Other

Check your shelf

Find Methylprednisolone aceponate in your products.

Scan any cosmetic product with LuxSense to see if it contains Methylprednisolone aceponate and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.