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N-METHYL-3-NITRO-P-PHENYLENEDIAMINE

CAS 2973-21-9
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A nitro-substituted phenylenediamine hair-dye precursor with EU Annex II/1284 restriction indicating high regulatory concern.

N-Methyl-3-nitro-p-phenylenediamine is a nitro-substituted p-phenylenediamine derivative listed in EU Annex II (reference II/1284), indicating it is prohibited from cosmetic use in the EU due to safety concerns. The nitro group (NO2) on a phenylenediamine scaffold creates significant toxicological concern, including potential for genotoxicity and methaemoglobin formation. The methylamino substituent at the N-position further modifies reactivity. This combination of structural alerts and explicit Annex II listing places it among the most restricted aromatic amine dyes in EU cosmetics regulation.

Known concerns

  • Listed in EU Annex II – prohibited from all cosmetic products in the EU
  • Nitro group on phenylenediamine – genotoxicity concern
  • Potential for methaemoglobin formation from nitro-aromatic metabolism
  • Not permitted in any EU cosmetic formulation regardless of concentration

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.