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N-RETINOYL DOPAMINE

40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A retinoid-like conjugate of retinoic acid and dopamine, listed under EU Annex II restriction II/21 due to vitamin A derivative concerns.

N-Retinoyl Dopamine is a covalent conjugate of all-trans retinoic acid and dopamine, combining the biological activity of retinoids with a neurotransmitter scaffold. EU CosIng lists restriction II/21 for this ingredient, which limits its use in cosmetic products — particularly in rinse-off formulations where exposure is lower, but nearly prohibiting it in leave-on products. Retinoids are well-documented teratogens and are restricted to very low levels in the EU, especially in body lotions and facial products.

Skin benefits

  • Retinoid-like anti-aging and cell renewal activity
  • Collagen stimulation and wrinkle reduction
  • Skin tone evening and hyperpigmentation reduction

Known concerns

  • EU Annex II/21 restriction limits cosmetic use
  • Retinoid activity — teratogenicity risk (Category 1B reproductive toxicant)
  • Skin irritation, erythema, and peeling at higher concentrations
  • Not suitable for pregnant or breastfeeding consumers

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.