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Skin Conditioning

NICOTINOYL PENTAPEPTIDE-20

CAS -
70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A pentapeptide conjugated to nicotinic acid (niacin). Designed to deliver niacin-like signalling with peptide-driven skin affinity.

Nicotinoyl pentapeptide-20 is a hybrid molecule: a 5-residue synthetic peptide acylated with nicotinic acid (vitamin B3/niacin). The rationale is to combine the established skin-barrier benefits associated with niacin-family ingredients with the targeted delivery profile of short peptides. Niacinamide itself has a robust CIR/SCCS safety record; nicotinic acid can cause transient flushing but typical topical esterified concentrations are far below symptomatic thresholds. This specific conjugate has not been independently reviewed by CIR or SCCS, and most efficacy data is supplier-generated. Use levels are in the ppm range.

Function

SKIN CONDITIONING

Skin benefits

  • Niacin-linked barrier signalling
  • Peptide improves formulation integration
  • Low irritation at use levels

Known concerns

  • Flush potential if hydrolysis releases free niacin in-skin
  • Limited independent evidence
  • No regulatory monograph for the conjugate

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.