Skin Conditioning
NICOTINOYL PENTAPEPTIDE-44
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A pentapeptide modified with a nicotinoyl (niacin-related) group for skin conditioning. Plausibly mild at trace levels; data is limited.
Nicotinoyl Pentapeptide-44 is a synthetic pentapeptide acylated with a nicotinoyl (pyridine-3-carbonyl, the acyl form of nicotinic acid) group. The strategy combines a peptide backbone with a niacin-related moiety, which suppliers market for combined signaling and brightening/antioxidant benefits. It is used at parts-per-million levels. There is no CIR or SCCS opinion specific to this peptide and no published GHS classification. Short peptides at trace levels show low irritation potential; nicotinoyl groups can in principle release small amounts of nicotinic acid (potential flushing in highly sensitive individuals) but at cosmetic peptide concentrations this is unlikely to be clinically meaningful. Independent efficacy data is sparse.
Function
Skin benefits
- Skin conditioning
- Possible mild brightening from nicotinoyl moiety
- Low irritation at trace levels
Known concerns
- No regulatory monograph
- Sparse independent data
- Theoretical flushing at high concentrations
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
Check your shelf
Find NICOTINOYL PENTAPEPTIDE-44 in your products.
Scan any cosmetic product with LuxSense to see if it contains NICOTINOYL PENTAPEPTIDE-44 and get a full ingredient breakdown with safety scores.
This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.