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Skin Conditioning

NICOTINOYL PENTAPEPTIDE-33

70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A five-amino-acid peptide with a niacin (B3) group attached. Used at micro-doses for brightening and skin-conditioning; generally mild.

Nicotinoyl pentapeptide-33 is a synthetic pentapeptide functionalized with a nicotinoyl group derived from niacin (vitamin B3). It pairs peptide chemistry with niacinamide-like effects such as brightening and barrier support. Used in leave-on skincare at ppm concentrations. Nicotinic acid derivatives may cause transient flushing in some users through prostaglandin-mediated vasodilation. No SCCS or CIR review for this specific peptide exists; efficacy data is supplier-generated. No GHS hazards apply at cosmetic use levels.

Function

ANTIOXIDANT, SKIN PROTECTING

Skin benefits

  • Niacin-peptide conjugate for brightening and barrier support
  • Trace-level use profile reduces exposure risk
  • Supplier data suggests skin-conditioning benefit

Known concerns

  • No SCCS or CIR dossier for this specific molecule
  • Potential for transient flushing from nicotinoyl chemistry
  • Efficacy based on proprietary studies

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.