Skin Conditioning
NICOTINOYL PENTAPEPTIDE-46
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A pentapeptide with a niacin-derived (nicotinoyl) cap, used for skin conditioning. Plausibly mild at trace levels; data is limited.
Nicotinoyl Pentapeptide-46 is a synthetic pentapeptide acylated with a nicotinoyl (pyridine-3-carbonyl) group derived from nicotinic acid. The combined structure is marketed for signaling plus mild brightening/antioxidant benefits and is used at parts-per-million levels. There is no CIR or SCCS opinion specific to this peptide and no published GHS classification. Short peptides have negligible intact skin penetration and low irritation potential at use levels; nicotinoyl groups can in principle release small amounts of nicotinic acid that may cause flushing in highly sensitive individuals at high doses, but at cosmetic peptide levels this is unlikely to be clinically meaningful. Independent efficacy data is sparse.
Function
Skin benefits
- Skin conditioning
- Possible mild brightening
- Low irritation at trace levels
Known concerns
- No regulatory monograph
- Sparse independent data
- Theoretical flushing at high concentrations
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.