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Skin Conditioning

NICOTINOYL TETRAPEPTIDE-140

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A tetrapeptide modified with a nicotinoyl (vitamin B3) group. Combines peptide and niacin chemistry as a skin-conditioning active.

Nicotinoyl tetrapeptide-140 is a synthetic four-amino-acid peptide modified with a nicotinoyl (vitamin B3-derived) acyl group. The design borrows from the well-tolerated chemistry of niacinamide and short cosmetic peptides, used at parts-per-million levels. There is no SCCS or CIR opinion specific to this conjugate; toxicology rests on supplier dossiers. Nicotinoyl conjugates can rarely cause a transient mild flush in highly sensitive users, similar to high-dose niacin.

Function

SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

Skin benefits

  • Niacin-coupled peptide for skin conditioning
  • Combines niacinamide-style and peptide chemistry
  • Trace use levels

Known concerns

  • Limited public toxicology on this specific conjugate
  • Possible mild flush in highly sensitive users
  • No SCCS or CIR opinion
  • Efficacy claims supplier-driven

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.