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NONOXYNOL-14

CAS 68412-54-4/ 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)
34

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

This mid-range ethoxylated Nonoxynol is restricted in EU cosmetics over concerns that its nonylphenyl component can generate endocrine-disrupting nonylphenol during use or environmental breakdown.

Nonoxynol-14 is a nonionic surfactant conforming to the polyethylene glycol mono(4-nonylphenyl) ether structure with an average of 14 ethylene oxide units. EU regulatory framework under REACH Annex XVII (entry 46a) prohibits its use in cosmetic formulations, reflecting the persistent concern around the alkylphenyl moiety across all ethoxylation chain lengths. Mid-range ethoxylated variants have moderate but non-negligible aquatic toxicity profiles.

Known concerns

  • EU REACH Annex XVII restriction in cosmetic products
  • Endocrine disruption potential via nonylphenyl degradation
  • Aquatic toxicity
  • Persistence in environmental compartments

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.