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NONOXYNOL-40

CAS 68412-54-4/ 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

This higher ethoxylated Nonoxynol has substantially lowered endocrine risk but is still prohibited in EU cosmetic products under REACH Annex XVII restrictions on the nonylphenol class.

Nonoxynol-40 is a polyethylene glycol mono(4-nonylphenyl) ether with an average of 40 ethylene oxide units. At this chain length, the compound is highly water-soluble and shows minimal degradation to nonylphenol under environmental conditions, with a correspondingly reduced aquatic toxicity profile. However, EU REACH Annex XVII entry 46a applies a blanket restriction to the nonylphenol ethoxylate class, and Nonoxynol-40 is included regardless of its more favorable toxicological profile.

Known concerns

  • EU REACH Annex XVII restriction in cosmetic products
  • Residual endocrine risk (nonylphenyl source)
  • Aquatic toxicity at trace levels
  • Persistence in wastewater

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.