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NONOXYNOL-44

CAS 68412-54-4/ 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)
50

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

One of the highest ethoxylated variants, this Nonoxynol has substantially reduced endocrine activity but remains subject to EU cosmetic restrictions due to its nonylphenyl structural class.

Nonoxynol-44 is a polyethylene glycol mono(4-nonylphenyl) ether with an average of 44 ethylene oxide units. Its very high ethoxylation imparts water solubility approaching that of PEG polymers, with minimal nonylphenol liberation under environmental conditions. Nonetheless, EU REACH Annex XVII entry 46a applies a class-level restriction to all nonylphenol ethoxylates in cosmetic formulations, and Nonoxynol-44 is not exempt. Aquatic toxicity concerns are substantially reduced relative to lower homologues.

Known concerns

  • EU REACH Annex XVII restriction in cosmetic products
  • Residual environmental persistence
  • Trace aquatic organism exposure
  • Nonylphenyl structural alert

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.