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Alkylphenol ethoxylate surfactant

NONOXYNOL-44

CAS 68412-54-4/ 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A high-ethoxylate cousin of nonoxynol-9 used as an industrial emulsifier. Modern formulators avoid the nonoxynol family because of dioxane residue, mucosal irritation, and environmental endocrine concerns.

Skin benefits

  • Non-ionic surfactant and emulsifier from the nonoxynol family, used historically to solubilise oils into water
  • Can serve as a co-emulsifier in rinse-off systems

Known concerns

  • Nonoxynol surfactants are flagged in the EU for potential 1,4-dioxane and ethylene oxide residues from manufacturing
  • Nonoxynol-9 and related members have known mucosal irritation profiles, raising class concerns
  • Strict limits exist on alkylphenol ethoxylates under REACH due to environmental endocrine activity
  • Largely phased out of modern cosmetic formulations in favour of safer surfactants

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related alkylphenol ethoxylate surfactants

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.