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NONOXYNOL-5

CAS 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)/ 26264-02-8/ 20636-48-0
21

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A low ethoxylated variant of the Nonoxynol family with significant endocrine disruption risk through nonylphenol release, and banned from cosmetic use in the EU.

Nonoxynol-5 is a nonionic surfactant with an average of 5 ethylene oxide units, placing it in the lower end of the ethoxylation range. Its relatively low hydrophilic-lipophilic balance makes it prone to environmental degradation to nonylphenol, a potent endocrine disruptor. EU REACH Annex XVII entry 46a restricts all nonylphenol ethoxylates in cosmetic products, and Nonoxynol-5's low ethoxylation degree places it among the most problematic variants in the series.

Known concerns

  • Category 1 endocrine disruptor potential (via nonylphenol)
  • EU Annex XVII ban in cosmetic products
  • Aquatic toxicity
  • Bioaccumulation potential
  • Degradation to nonylphenol

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.