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NONYL NONOXYNOL-7 PHOSPHATE

CAS 39464-64-7
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Nonyl Nonoxynol-7 Phosphate is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Nonyl Nonoxynol-7 Phosphate is a dinonylphenyl ethoxylate (7 mol EO average) converted to its phosphate ester. It carries confirmed GHS hazard statements: H302 (Harmful if swallowed), H315 (Causes skin irritation), and H319 (Causes serious eye irritation). The nonylphenol ethoxylate backbone raises significant concern under EU REACH due to endocrine-disrupting potential of nonylphenol degradation products. It is listed on EU Annex III of the Cosmetics Regulation with restrictions, and the phosphate group adds additional skin and eye irritation risk. Use in cosmetic formulations requires careful concentration control.

Skin benefits

  • Effective surfactant and emulsifier

Known concerns

  • H302: Harmful if swallowed
  • H315: Causes skin irritation
  • H319: Causes serious eye irritation
  • Endocrine-disrupting potential of nonylphenol backbone (EU REACH concern)
  • Skin sensitization risk from phosphate group

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.