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OCTOXYNOL-3

CAS 9002-93-1
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Octoxynol-3 is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Octoxynol-3, with only 3 ethylene oxide units, is the most lipophilic and therefore the most irritating variant in the octoxynol series. Short-chain alkylphenol ethoxylates are more toxic to aquatic organisms and degrade more rapidly—but to more persistent short-chain alkylphenols. In the EU context, these shorter-EO variants are viewed less favorably due to higher irritation potential and the environmental profile of their degradation products. Restricted or avoided in quality cosmetic formulations.

Known concerns

  • Higher skin/eye irritation potential than longer-chain variants
  • Aquatic toxicity of both the parent compound and degradation products
  • Endocrine-disrupting octylphenol metabolite

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.