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P-HYDROXYANISOLE

CAS 150-76-5
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A phenolic antioxidant (MEHQ) used as a polymerization inhibitor and skin conditioning agent; restricted under EU Annex III (III/95) due to endocrine-disrupting concerns and sensitization.

4-Hydroxyanisole (MEHQ) serves dual functions in cosmetics as a polymerization inhibitor for monomers and as a skin conditioning agent with antioxidant properties. However, the compound has demonstrated endocrine-disrupting activity in toxicological studies, raising concerns about its safety in leave-on cosmetic products. EU Regulation 1223/2009 Annex III listing (reference III/95) restricts its use to specified concentration limits and prohibits use in certain product types. The phenol structure contributes to skin irritation potential, and the SCCS has noted that the risk-benefit ratio for cosmetic use requires careful evaluation given the availability of safer alternatives.

Skin benefits

  • Antioxidant skin conditioning properties
  • Polymerization inhibition in cosmetic formulations

Known concerns

  • EU Annex III restriction (III/95) for endocrine-disrupting potential
  • Skin sensitization and irritation reported
  • Endocrine disruption concern identified by SCCS
  • Limited to specific product types and concentrations in EU

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.