Skip to content

Other

pholedrine

CAS 370-14-9
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Pholedrine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Pholedrine (4-hydroxy-N,N-dimethylamphetamine) is a sympathomimetic amine that acts as a vasoconstrictor. The compound has pharmaceutical rather than cosmetic function and is subject to medicinal product regulations in the EU. The European Medicines Agency (EMA) has assessed sympathomimetic amines for safety, and pholedrine's structural similarity to controlled substances raises regulatory concern. While not formally listed in EU Annex II cosmetics ban, its pharmaceutical classification creates significant barriers to cosmetic use, and it is effectively prohibited in cosmetic formulations due to its medicinal/pharmacological status.

Known concerns

  • Pharmaceutical/medicinal product classification in EU
  • Sympathomimetic amine with vasoconstrictor activity
  • Regulatory concern due to structural similarity to controlled substances
  • Not permitted in cosmetic formulations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

28
1-(4’-Aminophenylazo)-2-methyl- 4-(bis-2-hydroxyethyl) aminobenzene
Other
 28
2,2'-Bioxirane (1,2:3,4-Diepoxybutane)
Other
 28
2-((2-METHYLAMINO)ETHOXY)-P-PHENYLENEDIAMINE
Other
 28
2-(2,2-DIMETHOXY)ETHOXY-P-PHENYLENEDIAMINE
Other
 28
2-(2-(2-METHOXYETHOXY)ETHOXY)-P-PHENYLENEDIAMINE
Other
 28
2-(2-OXOBUTOXY)-P-PHENYLENEDIAMINE
Other
 28
2-(2-PROPENYLOXY)-P-PHENYLENEDIAMINE
Other
 28
2-Butyryl-3-hydroxy-5-thiocyclohexan-3-yl-cyclohex-2-en-1-one
Other

Check your shelf

Find pholedrine in your products.

Scan any cosmetic product with LuxSense to see if it contains pholedrine and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.