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Banned Substance

Picrotoxin

CAS 124-87-8
2

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Picrotoxin is a plant-derived neurotoxin and convulsant. It is on the EU prohibited list (Annex II) and must not appear in any cosmetic product. If found on a label, that is a serious red flag.

Skin benefits

  • None for cosmetic use

Known concerns

  • EU Cosmetic Regulation Annex II prohibited substance
  • Potent GABA-receptor antagonist; acutely neurotoxic
  • Causes convulsions at low doses; historical use as a poison
  • Should never appear in cosmetic products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.