Other
POLYLYSINE
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
Polylysine is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
Polylysine (ε-poly-L-lysine, CAS 25104-18-1) is a homopolymer of L-lysine produced by fermentation of Streptomyces albulus. It functions as an antimicrobial preservative with broad-spectrum activity against gram-positive and gram-negative bacteria, yeasts, and moulds. It is FDA GRAS-approved for food preservation and is gaining popularity in cosmetics as a 'clean' preservative alternative. Its cationic nature disrupts microbial cell membranes. Studies show low cytotoxicity to mammalian cells and good skin tolerance at typical cosmetic concentrations (0.01-0.5%).
Skin benefits
- Natural antimicrobial preservation
- Gentle on skin compared to traditional preservatives
- Biodegradable and eco-friendly
- Moisture retention from amino acid structure
Known concerns
- May cause mild irritation at high concentrations due to cationic charge
- Antimicrobial spectrum may be insufficient as a standalone preservative
- Interaction with anionic ingredients can reduce efficacy
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.