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REPAGERMANIUM

CAS 12758-40-6
58

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Repagermanium is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Repagermanium (also known as 2-carboxyethylgermanium sesquioxide) is an organogermanium compound that has been studied for immunomodulatory, antioxidant, and anti-tumour properties. It is not a standard or historically approved cosmetic ingredient in the EU and is more commonly associated with dietary supplement and pharmaceutical research contexts. The European Commission cosmetics database (Cosing) does not list it as an approved cosmetic ingredient, and its safety for topical use lacks comprehensive assessment. Germanium compounds in cosmetics are subject to heavy metal and trace element regulatory scrutiny.

Skin benefits

  • Reported antioxidant activity in vitro
  • Immunomodulatory properties claimed in supplement research

Known concerns

  • Not a standard or approved cosmetic ingredient in EU Cosing
  • Limited topical safety and toxicological data
  • Subject to heavy metal/trace element regulatory scrutiny
  • Nephrotoxicity reported with certain germanium compounds at high doses

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.