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SPERMIDINE HCL

CAS 334-50-9
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A naturally occurring polyamine salt listed in EU CosIng Annex II (entry II/411), indicating a CMR classification with severe restrictions on cosmetic use.

Spermidine is an endogenous aliphatic polyamine found in all living cells. Its hydrochloride salt is listed in EU CosIng Annex II under entry II/411, which bans or severely restricts the substance in cosmetic products. Annex II is the list of substances prohibited in cosmetic products across the EU. The restriction reflects concerns about the biological activity of polyamines at certain concentrations and their potential role in cellular proliferation, which raises safety questions for chronic topical exposure.

Skin benefits

  • May support cellular repair processes in anti-aging contexts

Known concerns

  • EU Annex II restricted (II/411) — severely limited cosmetic use
  • CMR (carcinogenic/mutagenic/reprotoxic) concerns at elevated exposure
  • Biological activity as a polyamine signaling molecule

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.