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SYNEPHRINE

CAS 94-07-5
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Synephrine is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Synephrine is a naturally occurring sympathomimetic amine structurally related to ephedrine. While not specifically restricted in EU cosmetic regulation, it raises concern due to potential cardiovascular effects (vasoconstriction, increased blood pressure), particularly when combined with caffeine or used at high concentrations. Some regulatory bodies have flagged sympathomimetic amines in cosmetics for review.

Skin benefits

  • May provide temporary skin-firming effects via vasoconstriction
  • Used in 'slimming' and anti-cellulite cosmetic formulations

Known concerns

  • Cardiovascular effects (vasoconstriction, blood pressure elevation)
  • Interaction risk with caffeine and cardiovascular medications
  • Not specifically restricted but under regulatory scrutiny

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.