Skin Conditioning
TETRAPEPTIDE-33
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A synthetic four-amino-acid peptide used for skin conditioning claims. Low-concern at cosmetic use levels but efficacy evidence is thin.
Tetrapeptide-33 is a proprietary synthetic tetrapeptide (four amino acids) used in cosmetic formulations for skin conditioning. Specific sequence and activity details are supplier-controlled. Synthetic peptides in this class are typically used at parts-per-million concentrations in serums and leave-on treatments. They are generally non-irritating and non-sensitizing. No SCCS, CIR, or FDA-specific review identified for tetrapeptide-33. Efficacy claims rely on supplier-commissioned studies rather than independent clinical trials. No GHS hazard category applies at cosmetic use levels.
Function
Skin benefits
- Synthetic peptide for skin conditioning
- Used at trace levels minimizing exposure
- Low irritation profile
Known concerns
- Limited independent efficacy evidence
- Proprietary structure with supplier-only data
- Topical bioavailability of peptides remains debated
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.