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Bioactive peptide

TETRAPEPTIDE-49

76

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic signal peptide promoted for skin firmness and renewal in anti-aging cosmetics. Used at trace levels with a good tolerance profile, although robust independent efficacy evidence is limited.

Function

SKIN CONDITIONING

Skin benefits

  • Marketed as a signal peptide for skin renewal and firmness
  • Used at very low concentrations, minimising systemic exposure
  • Generally well tolerated in patch tests on cosmetic peptides
  • Targeted bioactive ingredient with skin-conditioning claims

Known concerns

  • Independent peer-reviewed efficacy data is limited
  • Mostly supplier-supplied in vitro evidence
  • Stability and bioavailability through intact skin uncertain

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.