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TOLUENE-2,6-DIAMINE

CAS 823-40-5
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A diaminoaromatic compound used in oxidative hair dye systems, it is restricted to professional-use hair dye formulations in the EU (Annex II/413) due to its sensitisation potential as an aromatic amine.

Toluene-2,6-diamine (2,6-diaminotoluene, also CI 76045) is an aromatic diamine used as a primary intermediate in oxidative hair dye formulations, particularly in combination with couplers to produce yellow, orange, and red shades. In the EU it is listed in Annex II (prohibited substances) at entry 413, which requires interpretation: hair dye substances listed in Annex II are generally restricted rather than fully prohibited when used in the specific context of oxidative hair dyeing with proper controls. It is subject to strict maximum concentration limits at point of sale and point of use. Aromatic amines are known for contact sensitisation potential and require professional handling and patch test warnings.

Known concerns

  • EU Annex II/413 restricted — oxidative hair dye professional use only
  • Aromatic amine sensitisation potential (contact dermatitis risk)
  • Requires cautionary labelling and professional-use restrictions
  • Maximum concentration limit at point of mixing

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.